DELINEATION OF THE CRUCIAL EVOLUTIONARY AMINO ACID SITES IN TREHALOSE-6-PHOSPHATE SYNTHASE FROM HIGHER PLANTS

Delineation of the Crucial Evolutionary Amino Acid Sites in Trehalose-6-Phosphate Synthase From Higher Plants

Trehalose-6-phosphate synthase (TPS) is a key enzyme in the biosynthesis of trehalose, with its direct product, trehalose-6-phosphate, playing important roles in regulating whole-plant carbohydrate allocation and utilization.Genes encoding TPS constitute a multigene family in which functional divergence appears to have occurred repeatedly.To identi

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Calculating and comparing codon usage values in rare disease genes highlights codon clustering with disease-and tissue- specific hierarchy.

We designed a novel strategy to define codon usage bias (CUB) in 6 specific small cohorts of human genes.We calculated codon usage (CU) values in 29 non-disease-causing (NDC) and 31 disease-causing (DC) human genes which are highly expressed in 3 distinct tissues, kidney, muscle, and skin.We applied our strategy to the same selected genes annotated

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